Investigação e Desenvolvimento

Investigação e Desenvolvimento

A abordagem utilizada baseia-se na análise e integração de vários parâmetros em diferentes modelos celulares in vitro com o objectivo de criar modelos altamente preditivos de toxicidade humana fornecendo, simultaneamente, informações crucias para uma melhor compreensão dos mecanismos de toxicidade de substâncias químicas ao nível celular e de órgãos.

Publicações

Andreia Luís, João D Martins, Ana Silva, Isabel Ferreira, Maria T Cruz, Bruno Miguel Neves (2014).
Oxidative stress-dependent activation of the eIF2-ATF4 UPR branch by skin sensitizer DNFB modulates dendritic-like cell maturation and inflammatory status in a biphasic manner.
Accepted for publication in Free Radical Biology & Medicine
Silva A, Nunes C, Martins JD, Lopes MC, Dinis T, Neves BM, Cruz MT (2014).
Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways on dendritic-like cells.
Free Radic Biol Med. 2014 Jul;72:238-46.
Santinha DR, Dória ML, Neves BM, Maciel EA, Martins J, Helguero L, Domingues P, Cruz MT, Domingues MR.
Prospective phospholipid markers for skin sensitization prediction in keratinocytes: a phospholipidomic approach.
Arch Biochem Biophys. 2013 May;533(1-2):33-41
Neves BM, Rosa SC, Martins JD, Silva A, Gonçalo M, Lopes MC, Cruz MT.
Development of an in vitro dendritic cell-based test for skin sensitizer identification.
Chem Res Toxicol. 2013 Mar 18;26(3):368-78.
Santinha DR, Marques DR, Maciel EA, Simões CS, Rosa S, Neves BM, Macedo B, Domingues P, Cruz MT, Domingues MR.
Profiling changes triggered during maturation of dendritic cells: a lipidomic approach.
Anal Bioanal Chem. 2012 Apr;403(2):457-71.
Neves BM, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC, Cruz MT.
Signal transduction profile of chemical sensitisers in dendritic cells: an endpoint to be included in a cell-based in vitro alternative approach to hazard identification?
Toxicol Appl Pharmacol. 2011 Jan 15;250(2):87-95.
Francisco V, Neves BM, Cruz MT, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC.
Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: relevance of different signalling pathways.
Arch Dermatol Res. 2010 May;302(4):271-82.
Neves BM, Cruz MT, Francisco V, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC.
Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line.
Toxicol Lett. 2008 Feb 28;177(1):74-82.

Patentes

“METHOD FOR DETERMINING SKIN SENSITISATION POTENTIAL”
Patente PCT/PT2012/000018
“A quantitative approach to assess the potency of contact allergens”.
Pedido provisório de Patente nº 20131000080916
“Method for determining low molecular weight respiratory allergens”.
Pedido provisório de Patente nº 120141000021388

Prémios e Distinções

  • 2013

    Prémio Inovação e Empreendedorismo

  • 2012

    RIERC, Regional Business Ideas Competition, with Toxfinder test in vitro

  • 2011

    Cotec to Idea to® Product Competition, with the project Sensitizer Predictor

  • 2010

    Portuguese Governmant to Business Ideas Competition Arrisca Coimbra with the project "In vitro Test for detection of cutaneous allergic potential of chemicals: an imposition of the new European legislation".

  • 2010

    INOV.C, for the project "Detection of potential chemical skin sensitizers”

  • 2008

    Lierac, Grupo Ales, Paris, “Prix de Recherche Sientific Lierac” for the best project in clinical or fundamental research on skin physiopathology